人 DPYD (NM_001160301) cDNA克隆

基本信息

Accession: NM_001160301
基因名称: DPYD
基因别名: DHP; DPD; DHPDHASE
基因描述: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, mRNA.
种属: Human
CDS区长度: 522 (查看编码区序列)
翻译后氨基酸长度: 173 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G100363 人 DPYD (NM_001160301) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 DPYD (NM_000110) cDNA克隆 transcript variant 1
人 DPYD (NM_001160301) cDNA克隆 transcript variant 2

基因简介

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

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