人 FMO5 (NM_001144830) cDNA克隆

基本信息

Accession: NM_001144830
基因名称: FMO5
基因描述: Homo sapiens flavin containing monooxygenase 5 (FMO5), transcript variant 3, mRNA.
种属: Human
CDS区长度: 858 (查看编码区序列)
翻译后氨基酸长度: 285 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. This results in a frameshift and shorter protein (isoform 3), compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G100114 人 FMO5 (NM_001144830) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 FMO5 (NM_001461) cDNA克隆 transcript variant 1
人 FMO5 (NM_001144829) cDNA克隆 transcript variant 2
人 FMO5 (NM_001144830) cDNA克隆 transcript variant 3

基因简介

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

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